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Biology Ebola virus Ebola virus disease

The Cost of Complacency: Ebola Virus and the Deaths of Thousands

Ebola Virus - Centers for Disease Control and Prevention's Public Health Image Library/Wikimedia
Ebola Virus – Centers for Disease Control and Prevention’s Public Health Image Library/Wikimedia

One week before I wrote this post, a Liberian man named Thomas Duncan showed up at the same Dallas hospital he had come to four days before, except this time he rolled up to Texas Health Presbyterian Hospital in an ambulance. He has Ebola Virus Disease (EVD), which he likely contracted trying to help an EVD victim four days before leaving Liberia to visit family in Dallas. He is currently in critical condition, “fighting for his life.” My thoughts go out to him and his family.

I won’t rehash the details, because by now every person who hasn’t been camping in the wilderness for the last week knows the story.  (If you have been camping, welcome home. You can read NBC News’ timeline of events.)

The indifference and lack of action on this issue has troubled me for months now. It bothers me even more when I see articles like NPR’s No, Seriously, How Contagious is Ebola?

Nothing the article says is incorrect as far as I know – the basic reproduction number (R0) of this outbreak of Zaire Ebola virus (EBOV) is indeed in the neighbourhood of 2.0, and public health experts are saying that it is unlikely that we will see a major outbreak in places with modern infrastructure and health care.

Nigeria is a great example of what can be done with proper response. Nigeria is ranked as one of the worst health care systems in the world. A man caused the outbreak in Nigeria when he hopped on a plane from Monrovia to Lagos, eventually infecting 20 people. Eight people died, while 13 more were infected and survived. However, with fewer than 100 people exposed to the infected man, and basically getting the guy right to the hospital, Nigeria contained the outbreak. Officials were able to do contact tracing, creating a list of everyone who came in contact with the patient and were therefore at risk of contracting EBOV. With this list, they were able to monitor and isolate infected individuals. It has been five weeks since the last case in Nigeria, with no new cases since then. With proper response and infrastructure, the spread of EBOV can be stopped.

Now, that said… Dallas’ initial reaction was not as good as Lagos’, and that should concern us. In Dallas’ case, it is unlikely that any of the airplane passengers who shared the plane with the guy are infected. The epidemiological evidence right now indicates that Ebola virus is only contagious when the carrier is showing symptoms, and Thomas Duncan did not show symptoms until four days after he arrived in the US, approximately eight days after he was likely exposed to the virus. He was fine when he got on the plane; he was fine when he got off the plane.

When Duncan initially went to the hospital, his travel history was collected. He told them that he had just come from Liberia. According to the hospital’s original reports, this travel history was not available to his doctor, and they had rectified the software issue that caused that. However, as of last night the hospital changed its tune and said the doctor did have access to the travel history. And yet they still sent him home. With symptoms. For almost FOUR DAYS, until he was put in an ambulance and returned to the hospital.

Now, the good news is that the US authorities can and have done their own contact tracing, and they are monitoring closely. If there’s an organization that is capable of managing an outbreak, it’s the US CDC. The bad news is that the US’ much-praised health care system failed at the most basic detection and infection management. So keep that in mind when people say that the health care system is immune to an EVD outbreak: the health care system is made up of people and processes, and in this case both the people and the processes failed. More good news, though: I’m 100% certain that this case is causing health care professionals all over the world to be much more vigilant. We had two cases in the Toronto area where people had recently travelled to West Africa, and were isolated once they presented as symptomatic. Both tested negative for EBOV.

So, that’s all of the background for what I am about to say.

This is why the NPR  article really bothers me.

On March 24, the Guinean Ministry of Health and MSF (Medecins Sans Frontieres/Doctors Without Borders) notified the WHO of the outbreak in Guinea, and over the next couple of months started begging for help. Louder and louder. On June 22, MSF said the outbreak was “out of control”. Do you know when the WHO declared an international emergency? August 8.

Nobody in the developed world seemed to care, except to start comforting their own populations that it was unlikely that EBOV would show up in their country. Which is missing the point, because the whole “hey, we’re fine, so why should we care?” attitude is what has led to the international humanitarian crisis we are in now.

If the WHO, and major world governments, had snapped into action, they would have had a chance to contain it. Isolation and contact tracing are key techniques in stopping outbreaks of highly virulent communicable diseases. When there were a few dozen victims in rural areas, this was still possible, as it had been in all past EBOV outbreaks. The virus infects, reproduces itself, and the disease burns itself out by either killing its host or granting them ~10-year immunity if they survive.

We aren’t there any more. Conventional containment methods cannot work. There are simply not enough medical professionals or beds to receive and isolate all of the patients showing up at hospitals and treatment centres. People are vomiting and shitting themselves in taxis on the way to the hospital, where they lie outside (and sometimes die) waiting because the hospital is full. And then what will the next passenger do? There is no way to do contact tracing any more. In the middle of June 2014, EBOV made its way into Monrovia, the capital of Liberia. Monrovia has a population of a million people, many of whom live in close quarters in slums without electricity or running water. Think about what that means for the spread of this virus.

Our selfish complacency, facilitated by articles like this, has led us to a situation where this “modest” R0 of 1.5-2.5 is now doubling infections every three weeks. Every. Three. Weeks.

According to the latest statistics released by WHO, in the last nine days, the number of deaths has increased by 22% and the number of cases by 27-28%. (Well, it’s higher now, because those numbers were as of Friday. I am writing this on Sunday. Keep in mind that those two days make a difference, as we sit around and promise supplies, personnel, and financial aid. Dozens or hundreds more people have started showing symptoms since you and I left work on Friday. And they have no access to medical care until the patient occupying their bed dies or recovers. Think about that for a minute.)

Thousands of people have died; thousands more have been infected; and thousands beyond that have been exposed. The WHO reported ~3400 deaths and ~7500 cases as of October 3. The CDC says these numbers are vastly underreported, perhaps to the tune of 2-2.5x. People don’t go to the hospital, so they are staying at home, infecting the people around them… and in at least 50% of the cases, dying without ever being noticed by the authorities.

The NPR article quotes Thomas Frieden, the director of the CDC, as saying, “I have no doubt that we will control this importation, or case, of Ebola so that it does not spread widely in this country.”

Except here is something else that Frieden said, but the article omitted:

“The outbreak is even worse than I’d feared. … This is a threat not just to West Africa and to Africa, this is a threat to the world.”

Here is what Joanne Liu, the International President of MSF, said to the UN in mid-September:  (And remember how long two weeks is in this uncontained outbreak with a “not that impressive” R0 of 2.0 and a doubling time of  about three weeks.)

“We are unable to predict how the epidemic will spread. We are dealing largely with the unknown. But we do know that the number of recorded Ebola cases represents only a fraction of the real number of people infected. We do know that transmission rates are at unprecedented levels. We do know that communities are being decimated. And, with certainty, we know that the ground response remains totally, and lethally, inadequate.”

“With every passing week, the epidemic grows exponentially. With every passing week, the response becomes all the more complicated.”

While we probably shouldn’t be freaking out about our mom or our partner or or our kid getting EBOV (at least not yet), we should be freaking out about the fact that there’s a whole lot of talk and very little action to support the NGOs who are trying (and failing through no fault of their own, in spite of valiant efforts) to contain this outbreak. They simply cannot do the work that the world is hoping that they will do. By ignoring their pleas for help, we have set them up to fail. This is on us.

The minute migrant workers start moving from West Africa to other currently-unaffected African countries, or heading to other parts of the world like India, the world could be in deep fucking shit.

We need to be shaken out of our complacency – not next month, not next week. Now.

At this point the best case scenariobest case, assuming thousands of beds in isolation wards, and hundreds or thousands of medical professionals showing up with proper equipment and training–is that the outbreak will be over by the middle of 2015. They have no way to get the R0 under 1 right now. The longer it sits above 1, the more people will become infected. The more people will die. Thousands of people. Eventually tens of thousands. Maybe hundreds of thousands. All because we’re wringing our hands, making promises… and operating at the speed of bureaucracy. In the space of a week, an EVD victim can go from sick to dead. A week is really fast for bureaucracy. EBOV doesn’t wait for meetings to be convenient to your schedule.

That’s why we should be freaking out. Not because of our own families who are safe in Germany, Canada, Chile, Japan, and the US, but because of the hundreds of thousands or millions of people who could die because we’re telling ourselves everything will be fine.

Once all of this is over, we need to take a long, hard look at ourselves, and ask ourselves and our governments why we let it get this bad. We must stop it now, and this can never happen again.

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Biology Ebola virus Ebola virus disease

Ebola Virus Disease. Do Something. Now.

This Wired article about Ebola Virus Disease (EVD) comes to me via one of my favourite biologists. Here is a quote (from the article, not my friend) that should make you pay attention.

“I’ve spent enough time around public health people, in the US and in the field, to understand that they prefer to express themselves conservatively. So when they indulge in apocalyptic language, it is unusual, and notable.

“When one of the most senior disease detectives in the US begins talking about ‘plague,’ knowing how emotive that word can be, and another suggests calling out the military, it is time to start paying attention.”

Time for real talk.

If you’ve dumped ice water on your head or you’ve been angrily posting articles from Haaretz or al-Jazeera about Israelis and Palestinians lobbing explosive devices at each other… you are entirely justified, but this outbreak in west Africa has already killed more people than the 2014 bombing of Gaza, and almost as many as will die from ALS this year.

If your response is, “well, ALS still kills more people,” understand that this Ebola virus outbreak is growing literally exponentially, doubling in size every three weeks, and is currently out of control… and it has a fatality rate of about 75%, which means if you contract this strain of rapidly-mutating Ebola virus, you have a 1 in 4 chance of surviving it. Just wait a week or two and we’ll blow past the ALS numbers like they were standing still.

The most recent estimates for this outbreak, released at the end of last week, are that between 77,000 and 280,000 people could become infected. The number was three at the beginning of this year. In March, it was about one hundred. It’s now over 5000 confirmed cases (it’s probably much higher; many people aren’t reporting it because they don’t want to go to the hospital) now, in mid-September. In the next four months, by the end of the year, it could be somewhere between 77,000 and and 280,000.

Just to be clear, Ebola virus doesn’t go dormant on New Year’s Eve. If we don’t do something… do the math yourself.

The virus has already shown up in Nigeria, carried there by airplane, some 2,000 kilometers from where it started. The maximum incubation period for this species of Ebola is about three weeks (though eight to ten days is much more common, and two days is the fastest they’ve seen), which means someone could have it and not know it for three weeks. I’ve booked flights with less notice than that. Heck, I’ve booked flights with less notice than two days.

Do you want a political cause to be indignant about? Something that will take the lives of tens of thousands of innocent people, and irrevocably alter the lives of tens or hundreds of thousands of others, in countries with failing or failed health systems?  Something with no cure? Something that involves religious superstition, government ineptitude, and a lack of reasonable media coverage? Here’s a ready-made cause for you.

Ebola doesn’t care what race you are, or what religion you are, how much money you make, or anything like that. Its only job is to replicate itself, finding a new host, and probably killing its host in the process. And it’s really fucking good at its job.